Study of Scientific ArticleThe steps used in the scientific method were asfollows.
Their uses are also described.Case ascertainment – Used to draw data on AutismSpectrum Disorders (ASD) from national registriesMaternal supplement use – Recommendations forsupplements used by pregnant women during studyCovariates – Subjects that display ASD and which canbe influenced by multivitaminsOdds Ratio – Measures association between exposureand outcomeSibling matched analysis – Identifies siblings withshared characteristics (Frisell, Oberg, Kuja-Halkola and Sjolander, 713 – 720)Propensity score analyses (PSM) – Estimates effectsof treatment or other intervention by accounting for covariates receivingtreatmentsMultivariable regression analyses – Used to predictthe effect of a number of factors on a number of variablesMultivitamin categorization – Categorizing differentvitamin supplements based on their effect and functionMaternal hospitalstays – Used to study observed and unobserved health factorsOut of 273, 107subjects, children who were 4 to 15 years of age by December 31, 2011, and wereborn between 1996 and 2007A1 were taken assamples. The rest were considered as controls. The independent variables usedin the study were multivitamins, iron and folic acid.
The dependent variableswere ASD and intellectual disability.B.The treatment group included children over an 11-year period, andonly those whose complete birth data could be accessed were included in thestudy. The age group selected was the best for studying ASD and relateddisorders.
The controls were also selected from mother-child pairs whosecomplete data was available. In a scientific study with such importance, it isimportant to understand the background and health information of those beingstudied. Therefore, the selection was appropriate.Any study that includes so many statistical analyses is bound toestablish robust data Regression analysis was used to establish an associationbetween multivitamin use and occurrence of ASD and intellectual disability.Multivariable analysis is especially important because in this study more thanone independent variables were used to influence more than one dependent variableA2 (EC,23 – 28). Heresensitivity analysis was essential to identify a relationship between observedmaternal stays and unobserved health factors which may have risen due to theuse of multivitamins or a single component.
A3 A4 A5 A6 A7 A totalof 273, 107 subjects were studied. For a study of this complex nature, thesample size was good enough to establish a steady understanding of the proposedquestion.Althougha lot of confounding factors were present during the study, I think establishingthe fact that the use of anti-folates during pregnancy increases the chances ofASD (Wang, Li, Zhao and Li, 4 – 7) is a bit biased. While it is true thatscientific studies exist to support this claim, considering it as the truth,especially when it is an important part of the current study, is flawed (Adams et. al.1 – 30).
A8 Thestudy fails to establish a connection, even a minor one, between multivitaminuse in mothers and the risk of ASD in children born. Moreover, the number ofvitamins studied was less and may be a reason for the lack of adequate data.Although the number of samples was high, the study failed to consider the smallcell counts associated with rare findings which often makes it difficult toreach a conclusion.Despitethe dead-end reached by the study, the A9 resultsobtained provide a window into the relationship betweenmultivitamin use and ASD. The findings in this study are significantA10 A11 , and A12 the scientific methods used lays thegroundwork for future studies.
A13 A14 C.ASD andintellectual disability affect thousands worldwide, and therefore anunderstanding is required to educate the general mass as to why it happens. Itwill also help create a diagnostic method for quick evaluation of ASD andintellectual disability A15 in response to multivitamin use in mothers.
A16 The importance of thisstudy creates a space for other studies to grow. Also, the use of differentscientific methods helps me understand what works and what doesn’t. Researchingfor this study has tought on how to investigate, analyze and collect important informationto see if the evidence is valid or lacking validation.
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