Silicate bone marrow mesenchymal stem cells, and the

based bioceramics have been introduced as potential bioactive materials for
bone tissue regeneration due to their bioactivity and degradability. Calcium
silicate is one of the proven bioactive materials and is
responsible for bone tissue regeneration due to its in vivo osteointegration. But it has some drawbacks like poor
mechanical property and its fast degradation rate leading to a high Si ion
concentration which would have a negative effect on cell growth. Studies have
demonstrated that the physicochemical properties of bioceramics could be
improved by the incorporation of strontium which was found to have dual effects
of stimulating bone formation and reducing bone resorption. Strontium is an
important trace element in the human body and has be reported to play a special
role in bone remodelling, as it was found to promote bone formation and
osteoblasts replication while inhibiting bone resorption by osteoclasts. On the
other hand, Sr can potentially be substituted for Ca in bioceramics and
bioactive glasses to further improve their bioactivity and biological
performance. Studies demonstrated that the combination of the bioactive
elements such as Sr and Si was effective in regulating the osteogenic property of
human bone marrow mesenchymal stem cells, and the ionic products from the
bioceramics significantly enhanced the ALP activity and bone-related genes
expression. It has been revealed that the incorporation of Sr into calcium
silicate can decrease its degradation rate and stimulate the proliferation of
osteogenic cells while not change the apatite mineralization ability in
simulated body fluid (SBF).

of Sr2+ ions in to bioglass is also favorable for regeneration of
alveolar bone, root cementum and periodontal ligament which implies as Sr2SiO4
can be used a dental material also. Non cytotoxic effects of Sr2+
for human periodontal ligament fibroblasts (PDL cells) have reported and we can
recommend Sr2SiO4 for treating tooth resorption.

is widely acknowledged as a desirable property for orthopedic and dental
materials because an implanted or a filling material should be distinguished
from the neighboring anatomical bone and tooth structures. Radiopacity of the  material provides a contrast between adjacent
anatomical structures and filling material; and it improves the radiographic
diagnosis of voids and improper contours. Density and atomic number are the
main factors contributing to a material’s radiopacity and strontium can be used
to enhance the radiodensity of implants. 

the use of strontium silicate (Sr2SiO4) might have
significant therapeutic potential as a biomaterials for orthopedic or dental
applications because of its demonstrated bioactivity non toxicity and radiopacity.  The present study summarizes our efforts to
prepare and characterize strontium silicate powder, and investigate their
bioactivity, biodegradability and in vitro cell response.